Skin Bacteria to Prevent Cancer in Future

Image soruce: Prevent cancer Society

Many people may find it strange, but skin bacteria could be your first force of defense against deadly cancers. Of late, Richard Gallo, professor at University of California San Diego in the US, has confirmed that the skin layering called of Staphylococcus epidermidis found on human skin inhibit the growth of cancerous cells inside human body. The bacteria release a chemical “6-N-hydroxyaminopurine (6-HAP)” that kill several type of cancerous cells inside the skin itself.

The Skin microbiome (bacteria) produce antimicrobial peptides that is capable of fighting against pathogenic bacteria. Similarly, 6-HAP can be used to prevent cancer and inhibit the further growth of cancerous cells inside the skin. In the United States, around 1 million skin cancer cases are reported with most of them around 94% of the same relate to non-melanoma skin cancer. This type of cancer happen due to overexposure of skin to the UV rays emanating from sunlight.

A team of scientists discovered the S. epidermidis strain that creates 6-N-hydroxyaminopurine (6-HAP) compound. It is well known that 6-HAP is a biological molecule preventing the spread of transformed tumor cells leading to lower chance of developing skin tumors in humans.

Research Study Conducted on Mice is Successful

A research on mice disclosed that intravenous injections (IV) of 6-HAP every 48 hours over 15 days lead to no toxic effects. However, when the same diffused with melanoma cells in mice, the size of the tumor reduced by 50 %.

There is increasing evidence that the skin microbiome is an important element of human health. In fact, we previously reported that some bacteria on our skin produce antimicrobial peptides that defend against pathogenic bacteria such as, Staph aureus. In the case of S. epidermidis, it appears to also be adding a layer of protection against some forms of cancer, said Gallo, spearheading the research on this subject.

Another team of experts conducted their experiments on the possible relation between skin bacteria and cancer at the University of California, San Diego School of Medicine. Their molecular research on Staphylococcus epidermidisproduce again confirmed that the bacteria do prevent skin cancer in reality. As many as around 9000 people die every year in the US due to skin cancer. Such research will be extremely vital towards protecting these precious lives on time.

The American Academy of Dermatology, cautioned that around 20% of the Americans are likely to develop some sort of skin problems including growth of cancerous cells at one point in time in their lives. It happens due to over exposure of the skin to UV rays of sunlight alongside the humongous amount of toxic environment in the US. These research studies will definitely throw more light on how to prevent the Americans from falling prey to deadly Cancers.

The Research is Underway to Discover More on this Subject

The auto-produce of skin bacteria that are capable of producing specialized chemicals actually immunizes the patients and inhibits the growth of cancerous cells. Strangely enough, these chemicals are not poisonous for human skin at all.

Dr. Gallo pointed out that more study on this interesting development is underway and some more breakthrough can be expected in the next few days. Now, the focus is to know the formation of 6-HAP and then determine if a reduction in the chemical could invite skin cancer risk or any quantity of the chemical produced inside skin is all-effective to prevent skin melanoma.

References:

https://www.sciencedaily.com/releases/2018/03/180301103701.htm

http://advances.sciencemag.org/content/4/2/eaao4502

Life with Schizophrenia

 

Schizophrenia is one of the most misunderstood psychological disorders as people have various misconceptions about Schizophrenia. Let us debug these misconceptions by understanding what Schizophrenia really is.

Firstly, there are different types of Schizophrenia; all depending on the behavior of the person affected which has a distinct characteristic.

  1. Paranoid Schizophrenia

This is the most common occurring type of Schizophrenia. Patients of this subtype are affected more as they grow older when the symptoms start showing and thus it’s hard to find out.

This prompts them to have delusions and thus pushes the patient in a state where he or she starts hearing voices.

  1. Catatonic Schizophrenia

In this severe type schizophrenia, a patient faces disability in movements. Moreover, there are three major characteristic to this type.

  1. Catatonic Excitement
  2. Catatonic Stupor
  3. Stereotypic movement

In catatonic excitement, the patient goes through hyper activity. On the other hand, in catatonic stupor a patient moves slowly and sometimes is even frozen while doing some action like reading.

In stereotypic movement, a person keeps repeating a particular action without purpose without realizing that they are doing so.

  1. Disorganised Schizophrenia

This subtype of schizophrenia largely affects the thinking process of a patient. They tend to pronounce words differently in a disorganized manner making it difficult to understand.

It also happens so that their respond to a certain question would make no sense at all. There are cases in which the patient is unable to perform easy daily tasks like cooking or wearing clothes.

  1. Residual Schizophrenia

This form is a residual schizophrenia in which a person slowly turns back to normal life. It starts with performing everyday tasks in a normal manner and then the psychological disorders fade off with time.

Over 51 million people around the world suffer from Schizophrenia. Out of that, 2.2 million people in America alone live with this disorder.

In simplest terms, Schizophrenia is a disorder in which a person goes through depression along with much other mental instability, like hearing voices, hallucinating and sometimes even seeing things.

The most common symptoms of Schizophrenic are depression and hearing voices. These symptoms make it very difficult for a person, especially someone who has to take care of his or her family. The sad part is that people even today remain insensitive to the problems faced by people affected with Schizophrenia.

Dentists Found a New Way to Repair Teeth Naturally Using Alzheimer’s Drugs

Image source: Telegraph.co.uk

As we grow old, out natural capacity of the tooth also decreases. Sometimes, this leads to replacement of teeth. In that case, inorganic cements based on calcium or silicon-based mineral aggregates are filled. But often the cement fails to give that much normal mineral volume which is necessary in the gum. Also they often get infected resulting in more problems for the patient.

In case of a problem due to infection – using cements or fillings often lead to infections – which complicate the problem. If the infection is big then dentists finally extract the tooth out of the mouth.

So, scientists have now come forward with a natural solution. They have now found the innovative way of natural formation of reparative dentine by mobilization of stem cells in the tooth pulp.

The process involves delivering low dosage of glycogen synthase kinase (GSK-3) antagonists through collagen sponges that promote the restoration of dentine. After a few days, the sponge is degraded leading to replacement of complete and effective natural repair. It could do wonder in the field of dental science.

New Research on Dentine at King’s College

A team of researchers at King’s College in London has found another method of stimulating the renewal of living stem cells in tooth pulp through Alzheimer’s drug. Due to infection, the inner pulp of tooth can get infected. In order to prevent so, a thin band of dentine is applied to the tooth pulp to disinfect and seal the same. But sometime this remains far from satisfactory and requires more innovative and appropriate dental implant to correct the same.

A feature published in scientific reports stated that researchers from the Dental Institute at King’s College, London, have found a new remedy with stimulation of stem cells located within the pulp of the tooth to generate new dentine. It reduces the dependence upon external substance and methods like filings or cements.

Professor Paul Sharpe from King’s College London stated, “The simplicity of our approach makes it ideal as a clinical dental product for the natural treatment of large cavities, by providing both pulp protection and restoring dentine. In addition, using a drug that has already been tested in clinical trials for Alzheimer’s disease provides a real opportunity to get this dental treatment quickly into clinics, he added further.

Experts feel this is an exhaustive process. It will help to enhance the natural repairing ability of the teeth in regard to large cavities. The stimulation of the renewal of the stem cells will include Tideglusib (Substance) which is also useful to cure Alzheimer’s disease. Hope this new invention will help people get their dental implant done in a more natural and safer way.

Top 6 Apps to Sleep Better

Image source: Google App

A good 8-hour sleep is very hard to get these days. The use of various gadgets and apps from time to time keeps us distracted whole night and in the morning the daily work starts – hardly we get time to nap. However, not all apps are just for fun only. To begin with, there are a lot of high-quality sleeping apps that prompt people to sleep better, and feel refreshed in the following day.

The most common reasons why people stay awake in the night are; insomnia, excessive stress, late night works, watching TV, listening to songs and many more. The list is endless, but somehow one needs to sleep better to stay safe from various diseases while enhancing one’s immunity to fight diseases. Proper sleep is the cornerstone of a healthy mind, body and soul.

  • SleepBot for Android: This operating system is getting a lot of admirations from all across the globe for its effectiveness and user-friendly technology. The SleepBot for Android is such a magnificent app that can easily track sleep patterns and astutely measure whether you are having a good 8-hour sleep or not. It will also let you know whether you have snorted in the previous night or not. It supports waking alarm feature too which wakes you up just at the right time in the morning.
  • Jawbone UP: The Jawbone Up is another important sleeping app that helps users to track your sleep while ensuring whether you have a proper diet or not. It also has an intelligent sleep recognition feature that finds out whether you are sleeping lightly or deeply. Jawbone Up feature is available for both iOS and Android mobile apps.
  • Sleep Cycle: It is an iOS application that monitors your sleep habits and wakes you up at the break of the dawn. The app costs around $1 and you can avail it on your iphone smartphones and tablets. The app collects all data relating to your sleeping habits and informs you the same in the following morning.
  • Beddit: This app sends data from an ultra-thin film sensor under your bedsheet to an iOS mobile app installed in your iPhone. This works on the ballistocardiography (BCB) system, which measures cardiorespiratory functions from your respiration and heartbeats. It can measure sleep time, sleep latency and snorting as well.
  • eSleep: It is relatively a cheaper app costing just around $1. This app is invented by Vanke software. It plays various soothing tunes to let you sleep tension-free. Pink noise, white noise, nature noise and brown noise helps you to sleep peacefully because of their lower level of decibels.
  • Fitbit One: This is an extremely useful app for a good night sleep. You can easily fit it on your pocket. It keeps track of your physical activity and measures whether that is healthy for you or not. When you wish to sleep, simply fasten the fitbit app on your wristband and set it to sleep mode. It will record all your movements that you made in the previous night. Once you connect the app to its website, you will get the complete report on what kept you awake at night and for how much you slept last night. You can use both Android and iOS smartphone to collect FitBit data. This is currently available at $100 per piece.

These low-cost but high-quality sleeping apps help people to get the must-needed 8-hour sleep daily at the night time. So, what are you waiting for? Buy one such app today and sleep better – stay fit.

Head Transplant A Reality Now!

Image source: Businessinsider

If you think “Frankenstein” was merely a fictional character of Mary Shelley more than two hundred year back, then pause, and think again. In the world of science, nothing is impossible and if science wins then who knows you might see “head transplant” a reality.

The neurosurgeon who is on the verge of carrying out first human head transplant experiment is Dr Sergio Canavero. He is relentlessly trying to do something which the world perceives to be unethical, surreal and impractical. In fact, the experiment could take place anytime this year.

If he succeeds no matter how much controversial the world claims this HEAVEN (Head Anastomosis Venture) project to be – it can be life-giving for the neck-paralysed people to again return to normal life. One of the wheelchair users Valery Spiridonov, hailing from Russia, is ready to volunteer himself for this project.

The experiment will observe how a brain will be frozen to prevent brain cells from dying and then tubes would be attached to support veins and nerves. The spinal cord will be cut and repaired and then again stitched to the skin of the donor body.

Pre-Surgery Preparation

The Chicago-based Inventum Bioengineering Technologies (firm) has created a VR system that would help the patients prepare for the psychological reactions that they may encounter after a head transplant.

Inventum chief executive Alexander Pavlovick stated to media, ‘In preparing the patient of Heaven (Head Anastomosis Venture) to transition into a new body, virtual reality training will be used before the surgical procedure to prevent the occurrence of unexpected psychological reactions. We are combining the latest advancements in virtual reality to develop the world’s first protocol for preparing the patient for bodily freedom after the transplantation procedure.’

First Human Head Transplant in 2017

The sharpest knife will be used to cut the spinal cord to a millionth of meter size during the process. Then it will be again repaired before using electrical stimulation to functionalise the nerves. It can even bring movement in a fresh dead body too with electrical tests as it stimulates the entire nervous system.

In fact, Dr Canavero and his friends have carried similar experiment in dogs which stood semi-success. A neck-paralysed dog was about to walk free and wag its tail post this experiment. However, critics argued that even if the experiment was semi-successful in animals, there is no guarantee of its success in humans.

The Expected Procedure of Head Transplant

A new person would need a transplant donor – already declared brain dead.

Heads of both the patient and his donor would be cut simultaneously.

Patient’s head will be affixed to the brain-dead donor using Polythylene gylcol.

It will be injected between the two ends for a clean fusion.

The patient will be put in a coma to recover properly while his muscles and blood supply get stitched.

When patient will come out of medically-induced coma, it is expected that he will be able to behave normally.

 

 

Warning: An Armageddon in the Waiting?

The majority of the medical experts feel that such experiments would be futile in case of humans. All of them have echoed that such a surgery will result in sure death. In fact, many feel that “Head transplant” could be actually worse than death – it may bring the horrific scenes of half-dead people like Zombies walking down the streets to real.

The latest news said that the project code named “Heaven” (Head Anastomosis Venture) will be postponed due to non-availability of volunteers. The Russian man Valery Spiridonov might backtrack since his girlfriend is not agreeing to his participation in volunteering with the HEAVEN project.